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Medical Device Design & Equipment Development

12 Posts tagged with the innovation tag
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Image that was controlled via Kinect during operation. (via Microsoft)

 

The Kinect imaging sensor has been used in some technically innovative projects such as Queen’s University’s 3D video conferencing system to Microsoft’s own augmented reality MirageTable. It’s even found its way into the medical field with a recent successful operation involving the repair of an aneurism at Guy’s and St Thomas’ hospital in London.

 

Surgeons involved in complex operations occasionally need to refer to reference material to help them through certain procedures. This is typically done by using an assistant to bring up the materials on a laptop so the doctor can remain at the operating table without having to waste time re-scrubbing because of contamination. This is where a new 3D imaging system that was developed by Microsoft Research Cambridge with Guy’s and St Thomas’ hospital can be invaluable as it was used for the first time by assistant surgeon Tom Carrell to perform heart surgery.

 

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Promotional image of the Kinect during surgery. (via Microsoft & St. Thomas' Hospital)

 

The system was used to compare a 3D model of an aorta with a live-feed 2D image of the patient's by using a fluoroscopic x-ray camera to help Carrell navigate through the delicate procedure. The 3D model could also be manipulated through a series of minimal gestures that include the ability to rotate the image using the palm of your hand and placing a marker simply by pointing and using a voice command. These simple gestures can be performed using only one hand leaving the other to continue the surgery while others, such as panning, rotating or zooming in/out need the use of both hands. Not only can the system be used in confined spaces commonly found in operating theaters, it also saves valuable time in eliminating the need to take a break to consult reference material.

 

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Composite image of the two companies technologies (via Withings & BodyMedia)

 

When it comes to weight loss, most people could use all the help they can get. The companies Withings and BodyMedia, Inc. are teaming up to provide those who wish to get fit and stay in shape with as much assistance as they can muster. The partnership is designed to bring together the functions of the Withings Wi-Fi Body Scale and the BodyMedia FIT system.

 

 

The Withings scale can collect data on the user’s body weight, lean mass and fat mass and body mass index (BMI). It allows 8 users at a time to store their information and access it through the Withings smartphone app or your own secure web page. The BodyMedia FIT armbands collect all sorts of physiological data like heat flux, skin temperature, motion and galvanic skin response at over 5,000 readings per minute.

 

 

Now, both of these devices automatically transmit all of their acquired data to the BodyMedia FIT Activity Monitor via their built in Wi-Fi making it extremely convenient to create graphs and charts of data and, one would hope, the motivation or value that would impulse one into exercising. The Withings scale is even able to update tweets and your facebook status with details of your getting healthy journey to get as much support from your friends online.

 

 

The Withings Wi-Fi Scale will set you back $160, and the BodyMedia FIT system equipment array is paralleling the price.

 

 

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(via The Institute for Intelligent Systems and Robotics (ISIR))

 

Technology that helps robots navigate and interact with their environment may soon help blind people in much the same way. A new type of glasses that takes advantage of 3D navigation that some robots use are currently being designed by Edwige Pissaloux and his team from the Institute of Intelligent Systems and Robotics located in France. The design uses a headset imaging system that takes 3D images and sends them to a handheld device that converts it to braille that the user can read which gives the blind a different way to see their environment. The headset consists of two cameras mounted on either side of the wearer which in tandem takes 3D images. A processor then analyzes the images and identifies various objects in the cameras field of view such as walls and other objects and builds a 3D map of the area. A series of accelerometers and gyroscopes monitors the user’s location and speed to determine the wearer’s relative position in relation to the 3D map. The compiled data is then sent to a tactile feedback display that produces a constant 3D map in braille form (at a rate of ten maps per-second) the gives the user a way of ‘seeing’ their environment in real-time.

 

The IISR team in France is also looking to combine their system with software being developed by engineers at the University of Nevada that was initially used to tell robots how far they have travelled based on its sensors (accelerometer/gyroscope). Their system uses smartphones internal sensors along with available 2D in-door maps and synthetic speech (SIRI?) to help the blind navigate. In order for the system to be effective, the phone must be calibrated to the users stride. This is done touching a series of stationary markers such as walls, hallway entrances and other obstacles. Both systems combined would greatly benefit the user’s ability to navigate just about anywhere in an urban environment. As to when this system/s will become readily available is anyone’s guess but then again ‘seeing is believing’.

 

It seems the scientific community is bent on technology returning sight to the blind. Read about more efforts in the area after this link.

 

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Bionic Vision, At Last

Posted by Cabe Atwell May 9, 2012

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Bionic Eye concept (via Bionic Vision Australia)

 

Most of us go our days taking for granted our sense of vision, but loss of this sense changes everything. Even though vision loss can occur for many different reasons, there is little medical science can do to fix most cases of blindness. However, technology is catching up. Retinal implants are already here, and next year a computer aided “bionic” eye will be tested on a human patient.

 

 

An Australian company, Bionic Vision Australia is teaming up with scientists from a new $2.5 million facility, the Rs.12.76 Crore Fabrication Facility, found at the University of New South Wales to develop prototype bionic eyes. These first prototypes will be helpful to patients with degenerative retinal conditions. To benefit from one of these bionic eyes, patients need to have a complete and functioning visual pathway from the retina to the brain and some intact retinal cells.

 

 

These prototypes are intended to give patients limited visual capabilities. This will be accomplished by use of a chip inside the transplant, which is connected to the nerve cells in the retina that send signals to the visual cortex. Impressively, the signal is captured via a video camera found on a pair of glasses worn by the patient that wirelessly relay it to a processing computer, and even a smartphone could do the job. After processing, it is sent to the bionic eye’s chip connected to retinal cells.

 

 

The sensor is made of biocompatible material and includes 98 electrodes that stimulate surviving nerve cells. Development and manufacture of the bionic eye will be greatly accelerated at the Rs.12.76 Fabrication Facility where the two prototypes are in development. This facility is stacked with state of the art equipment including laser cutters, plasma reactors, high temperature presses, probing machines and even a “clean room” for manufacturing electrical components.

 

 

The first prototype is a “wide-view” device that will help some visually impaired to easily detect between light and dark and allow them to see outlines of big objects for easier navigation around their environment. The second prototype is a “high-acuity” bionic eye that will provide a higher definition and will allow patients to read large fonts and recognize faces. They hope to have the second prototype ready for testing in four years.

 

 

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(Left) Implant behind eye. (Right) Retinal scan showing the sensor chip in place. (via University of Oxford)

 

Diagnosed with retinitis pigmentosa, the first symptom was night blindness. A few years later, vision was drastically reduced. Finally, another disease brought complete blindness in the left eye and the inability to distinguish light on the right. Chris James, a fifty-four year old council worker in Wiltshire U.K., had his life completely changed by his complications. He said, "It’s something you have to come to terms with and make the best of what you’ve got."

 

Chris James's new eye was switched on for the first time. The digital circuits flood with electricity. James could see light against a black background for the first time in decades. The retinal implants were a success. "As soon as I had this flash in my eye, this confirmed that my optic nerves are functioning properly which is a really promising sign. It was like someone taking a photo with a flashbulb, a pulsating light, I recognized it instantly."

 

Chris James was one of the first patients (along with Robin Millar, a 60 year old music producer) suffering from retinitis pigmentosa to receive retinal implanted circuitry to detect light and images from a collaboration between the University of Oxford (UO) and the company "Retina Implants" form Germany. A team led by ophthalmology professor Robert MacLaren were able to help the patients regain some semblance of vision. As the patients continue to use the implants, their vision continues to improve. Currently, the patients can see light differences and basic shapes.

 

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X-ray image of the complete system installed into Chris James. (via University of Oxford)

 

The implant is a 3mm square chip containing 1,500 light sensitive diodes. The chip is attached to the back of the eye where a signal can be sent between electrodes and the patient's optical nerves. The system is powered by an implanted power supply buried behind the ear, similar to some cochlear devices. Professor MacLaren explained that the sensor will "stimulate the overlying nerves to create a pixellated image." He continued, "Apart from a hearing aid like device behind the ear, you would not know a patient had one implanted.  We are all delighted with these initial results. The vision is different to normal , and it requires a different type of brain processing. We hope, however, that the electronic chips will provide independence for many people who are blind from retinitis pigmentosa."

 

The U.K based trials will continue with 12 patients overall thanks to funding from the National Institute of Health Research and the Oxford Biomedical Research Centre.

 

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Technology overview (via MicroChips Inc.)

 

Daily injections of medicine may be crucial for patients who suffer from certain diseases.  However, the pain involved may deter some patients from following their prescribed regiments , and this can lead to ineffective treatment. The company Microchips Inc., along with two other commercial companies, scientists at Harvard, MIT and the Case Western Reserve are developing a microchip system that could deliver individual doses of medicine while monitoring levels in the blood wirelessly.

 

 

The device was implanted and tried successfully in seven women who suffered from postmenopausal osteoporosis.  The drug to treat osteoporosis, teriparatide, is to be injected daily for two years , and it works to build bone if given intermittently so it was the ideal candidate for preliminary testing of this device.

 

 

A single microchip is 1/15’’ thick, ½’’ long and 1/5’’ wide and is implanted using local anesthetics under the skin of the abdomen. The entire system is 2 ¼’’ long and 1 ½’’ wide and made up of two chips located on the surface of its titanium housing. Each chip contains 10 individual cubic reservoirs, each measuring 0.04 in wide, capable of holding 600 nanoliters of the medicine.

 

 

Each reservoir faces the patient’s skin and is covered with a metallic membrane made of a titanium and platinum composite. These membranes are connected to internal circuits, which deliver currents to the membranes to dissolve them and release the drug.

 

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A close up of how the system works (via MicroChips Inc.)

 

This drug delivery system could be used to treat multiple sclerosis and chronic pain, but limitations to this device are clear in that they cannot be used to treat Diabetics because there is not enough room in the chip to store all the insulin needed. The company estimates that it will take 2 years to develop a chip that can deliver medicine for 365 days.

 

 

Many more human trials are needed to prove this technology is safe. Microchips Inc plans to file for FDA approval in 2014 , but the device will need 2 more years of clinical studies so it will not be available commercially until late in the decade.

No toxic effects were observed in the trial, although a faulty circuit prevented the drug from being released in the 8th patient. Blood tests showed that the quantity of the automatic doses was more consistent than shots and the drug was effective in generating bone growth.

 

 

Robert Farra, President and CEO of Microchips Inc announced that the cost of the implant and treatment would be around $10,000-12,000, which is very similar to price of standard injections.

 

 

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Cochlear implant concept (via University of Utah)

 

Cochlear implants have improved the hearing for over 220,000 deaf people around the globe, but they have their drawbacks. Not being able to swim or wear helmets comfortably due to the delicate microphone and related electronics worn on the outside of the ear are just some of the tip of the limitation. A team of engineers, led by Associate Professor Darrin Young from the University of Utah, are looking to fix those issues by implanting the cochlear microphone inside the ear itself, giving the user an increased level of freedom in otherwise damaging environments.

 

Typical implants house the microphone, signal processor and transmitter coil in a plastic shroud worn behind the ear. The mic picks up sound and sends it to an internal receiver-stimulator attached to bone under the skin by the microphone housing. From there, sound is sent to electrodes attached to cochlea which in-turn stimulates auditory nerves making it possible for the user to hear. Young’s design places all the external components normally worn outside the ear inside by placing an accelerometer sensor that’s attached to a chip on the ears umbo part of the tympanic membrane to detect vibration. This converts sound into electrical signals that are then sent to the electrodes attached to the cochlea which is powered by an implanted battery enabling the user to hear.

 

Recharging the battery is done at night while the user sleeps using a charger located behind the user’s ear in much the same fashion as wearing a typical cochlear implant. Successful testing was done using several cadavers (yes, you read that right) implanted with the new cochlear system. A laser was then used to measure the vibration on bones inside the ear to see which one was more efficient at picking up normal-level sound after which it was found that the umbo was the most successful. In order to test this device, the implanted microphone was wired to speakers with Beethoven’s Ninth Symphony acting as the test medium. While the sound was ‘muffled,’ Young states that ‘the muffling can be filtered out’. The team hopes to improve the overall sound quality in future versions so clinical trials are still a few years away but anything that can assist the disabled is still a hopeful future.

 

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(repost)

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(Left) Concept of the system (Right) Drawing of the MEMS generator (Via Purdue University)

 

A new medical pressure sensitive implant, microelectromechanical system (MEMS), is out that uses sound as a power source. This MEMS device is a sensor that monitors the pressure of the urinary ladder and in the sack of blood vessel damages by an aneurism. Purdue University researches invented the MEMS to one day treat people with aneurism or incontinence due to paralysis patients.

 

The MEMS device uses a vibrating cantilever that is connected to the bottom of the heart by a thin. The cantilever vibrates when music is within the range of frequencies of 200-500 hertz. When the cantilever vibrates it generates electricity, and that charge is stored in a small onboard supercapacitor. When the frequency falls out of the useful range, the cantilever stops vibrating and will automatically send the electrical charge to the sensor. At the same time, the system will take the pressure readings and transmits the data wirelessly.

 

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MEMS generator (via Purdue University)

 

The cantilever beam is a ceramic based lead zirconate titante material, a piezoelectric (PZT)element. The sensor is about two centimeters long. Researcher even tested the device in a water-filled balloon to see if still worked, and the test was a success. To get this device powered you can use batteries or an external transmitter.

 

The four genres tested with the MEMS were rap, blues, jazz, and rock. Among the four genres of music tested, rap rise above all when being the most effective. "Rap is the best because it contains a lot of low frequency sound, notably the bass," Purdue professor Babak Ziaie said. In rap, the vulgar words and the deep bass are put together for the listener to understand the true power of the message, which does not give the rap genre the best reputation. Soon, doctors using the device will understand the true power of Tupac songs.

 

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(repost)

 

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Japanese company Riken has partnered up with Tokai Rubber in the creation of the RIBA II nursing assistant robot. At the joint laboratory RTC, RIKEN-TRI Collaboration Center for Human-Interactive Robot Research, they have taken the RIBA Robot, from 2008, and upgraded the lifting abilities (by 41 lbs) and control interface to the point where it will be a tool for medical use.

 

I know a few hospital volunteers that say they have to lift elderly, sick, and disabled people in and out of beds and chairs routinely throughout the day. Depending on the condition of the patient, they say it can be an extremely difficult and cumbersome task to handle. This is where the RIBA II come in to play.

 

The 507 lbs (230 kg) robot can handle patients of up to 176 lbs (80 kg). Each are in covered in soft rubber, and has 7 degrees of freedom. The head has 3, waist has 2, and the omni-directional base has 3 more degrees of freedom. A touchscreen on the RIBA II bot's back will allow nurses to direct the bot to locations. Onboard laser range finders, proximity sensors, bumper sensors, and voice commands will help the RIBA II avoid obstacles and prevent accidents.

 

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Direct control of the RIBA II is the most innovative addition to the platform. The robot is covered in "Smart Rubber" that is the world's first capacitive touch rubber surface.  The sensors are on the bot's upper arms, forearms, hands, and chest. A nurse can then physically guide the bot quickly and make adjustments on the fly for hoisting the patient. Like the RIBA I, the RIBA II's Tokai Rubber also detect slippage and will adjust on its own to keep the patient comfortable.

 

RIBA II has the same "bear" head that was on the original RIBA. The designers claim this is to not scare the patient. The original lifting bot RI-MAN, which could only handle 41 lbs (18 kg), was a little scary. I question the use of either head. It is just a tool, right? A human forklift, in other words. Make it as non-anthropomorphized as possible, in my opinion.

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(RI-MAN by RIKEN)

 

 

When available in 2015, the RIBA II will cost $77,000 USD (6,000,000 JPY). Much more expensive than the free volunteers most hospitals depend on.


video via youtube member kmoriyama

 

(All pictures via RIKEN)

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(repost)

 

Showa Hanako is a dental training robot developed by the department of Orthodontics at the Showa University (SU) in Japan. The PVC skinned bot would move in a limited fashion using a hydraulic system. Limited movement and speech capabilities were built in. This bot was the 3rd generation of the University's line of training robots. Some of the complaints were the un-lifelike skin, odd stare, and the motion of the overall system. The Showa Hanako was never available for wide spread distribution due to the designer  Tmsuk's inability to handle  global repair issues. But all this is soon to change.

 

Showa University is going to attempt wide spread sales of their new upgraded Showa Hanako 2 dental training robot. This new bot swaps the PVC skin for realistic silicon skin. It now has an upgraded mouth with 2 degrees of movement for the tongue. The whole body has switch to motor actuation. The bot blinks, sneezes, coughs, shakes its head, gets tired of holding its mouth open, and has an expanding vocabulary. The smooth realistic oral cavity is currently being put through the patent process. IT software company, RayTron, has built in a voice recognition system able to hear a masked dentist and respond accordingly.

 

The sudden upgrade of parts comes from the Japanese company Orient Industries (OI), famous for "love dolls." OI has been build human shaped dolls since 1977. Their "Real Love Doll" line has figures with silicon skin with every joint movable in natural human positions. SU even admitted they needed OI's help in creating a realistic patient down to every detail. "Even the smallest mistake would be unforgivable."

 

More on the Showa Hanako 2 :

The Showa Hanako 2 even vomits when a student user touches the uvula (sensor).

 


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DNA nanorobot from Wyss Institute on Vimeo

 

 

Star Trek's "Borg" use nano-probes for cell-repair and to fight unwanted intrusion inside their human/robot bodies. It sounds like an effective way of fighting damaged cells, but it is science fiction. However, this Star Treks technology may be brought into reality for fighting off diseased cells (cancer) with the help of DNA origami. Designed by Paul Rothemund at CIT (California Institute of Technology), DNA origami is the folding of a single DNA strand into various two and three dimensional shapes.

 

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Programmable DNA nanorobot concept model. (via Wyss Institute & Campbell Strong, Shawn Douglas, and Gaël McGill using Molecular Maya and cadnano)

 

These can be made into a different number of things such as miniature images or even a programmable robot. Harvard University's Wyss Institute researcher Shawn Douglas, and his team, have created a barrel-like nano-robot that can deliver a dose of medicine to diseased cells. The ‘barrel’ is held shut by two DNA ‘latches’ that only release and introduce the medicine when they encounter specific cell proteins found in cancer. The team has tested this application with both leukemia and lymphoma cells that were mixed in with non-diseased cells. The nano-robots were programmed to seek out and deliver their payload known to kill those disease cells respectively. After a three day test period, the robots effectively killed around half of the cancerous cells without harming the healthy ones. Think of it as a super-mechanical white blood cell that homes in on cells that are in distress and targets them for termination.

 

This method is by no means and end-all to the cancer problem as it is still in the development stage and has not been run through clinical trials. The team has encountered some challenges along the way as to programming, shape of the nano-robot, method of medicine delivery and a host of other problems. However, any hope for an effective treatment for battling cancer is excellent news and should be viewed as such.

 

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The Department of Chemistry at Pennsylvania State University may have just built the future power plant for inner-human body robotics. At just 3.6 micrometers long, a rod consisting of copper (Cu) and Platinum (Pt) acts as both a battery and a motor. Researchers Dr. Ran Liu and Professor Ayusman Sen both believe this nanomotor-battery could be a different way to control drug administration.

 

The Cu-Pt rod, when placed in a solution of bromine or iodine (an oxidant), the Cu portion acts as an anode (with oxidizing) and the Pt part functions as a cathode. As the battery discharges, electrophoresis begins forcing the rod to move. In other words, the battery is short-circuited and the current produced is then changed to mechanical force.

 

The nanomotor effect continues until the Cu portion is completely oxidized. Adjusting the length of Cu changes how long or fast the rod moves. In the experiments, the movement lasted 40 seconds to 1 minute. Shorter lengths of Cu makes the motor move faster, but for a shorter time. The opposite is true for longer segments. By polishing one side of the Co end, the rod will act like a rotor. Making an asymmetrical end causes the rod to rotate up to speeds of 170 rpm (in bromine). 

 

The team's next step is to see if the battery/nanomotor can be recharged or reused. This is definitely smaller than the current alternative.

 

Eavesdropper