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It seems your question is answered in the manual - see page 10 of http://www.farnell.com/datasheets/2362522.pdf:
If you read the attached link, you will see that this relies on programming the OTP - https://github.com/pi-desktop/pi-desktop/blob/master/Boot-From-a-USB-Mass-Storage-Device/Boot-From-a-USB-Mass-Storage-De…
It's not without its problems - some people do complain that it doesn't work (e.g. https://www.element14.com/community/message/244194/l/pi-desktop-wont-boot-from-msata-pci-e-ssd#244194), doens't work reliably on a reboot (PI desktop: unable to reboot when booting from SSD , https://github.com/pi-desktop/deb-make/issues/2, Pi Desktop very disappointing ) or it takes longer to boot without the microSD card. I encourage you to do your own research on this rather than expecting someone else to pony up the answers.
Full disclosure - I don't own one of these cases myself and have not tried it myself.
Thanks Gough for the assistance. I will give these links a read. I just thought t would make more sense to boot from the big drive vs the micro SD card.
If one were to place a mSata hard drive into this unit, is the unit able to boot and run off of the mSata drive? Or does it still need the micro SD card to boot?